DSC– Differential Scanning Calorimetry. Evaluation of a sample’s thermal behavior, g. melting temperature, glass transition temperature, crystallization temperature etc.
TGA– Thermal Gravimetric Analysis. Determination of change in weight as a response to change in temperature, g. quantification of residual solvents.
GVS– Gravimetric Vapor Sorption. Evaluation of hygroscopicity, water sorption behavior at different relative humidity’s, deliquescence and other humidity induced phase changes.
TAM– Thermal Activity Monitor (microcalorimetry). Evaluation of any type of biological, chemical and physical process by detection and quantification of the related heat flow (exothermic or endothermic).
BET–Determination of specific surface area on powders (using N2 adsorption according to Brunauer – Emmett – Teller – principle). Determination of micro pore volume and meso pore distribution of solid samples.
Pycnometry– Helium based instrument used for the determination of absolute density of powders.
Analytical Methods and Techniques
LM– Light Microscopy. Optical microscope equipped with crossed polarized filters and camera functionality. Also available in inversed (from bottom) mode.
IR– Infrared spectroscopy. Identification of compounds, quantification of content and characterization of interactions in mixtures.
Micronisation – Particle size reduction using spiral jet mill
Conditioning – Restoration of crystallinity after micronisation with maintained particle size/distribution
SEM – High magnification Scanning Electron Microscopy
SXRD – Crystal structure determination by single crystal X-ray diffraction
Salt & Polymorph screening – Identification of the most optimum form for further development
Identification of API crystal modification – down to 0.01% in ordered mixtures
Crystallisation – Applying specialised methodologies to crystallise difficult compounds
Device verification Tools
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