Spray Pattern and Plume Geometry
Inhalation product development involves the analysis of the aerosol characteristics of the product. Aerosol generation of these products is achieved by using inhalation devices, typically metered dose inhalers (MDI), dry powder inhalers (DPI) or aqueous systems such as nasal sprays and nebulisers.
The preferred technology for characterisation is high-speed video imaging, where the plume geometry and spray pattern are accessed and documented. Typical information that can be assessed are length, width, angle, velocity or plume duration. Regulatory authorities also require these parameters to be documented1,2 in the filing of inhalation product development.
MVIC has the capability to perform high-speed video characterisation of aerosol plume geometry and spray pattern using LaVision imaging systems. This is done using single or dual camera systems, and the plume can be visualized using laser or conventional white light.
1 FDA Guidance for Industry, 2002. Nasal spray and inhalation solution, suspension, and spray drug products – CMC documentation.
2 FDA Guidance for Industry (draft), 2003 Bioavailability and bioequivalence studies for nasal aerosol and nasal sprays for local action.